Mortality determinants in colorectal cancer patients at different grades: a prospective, cohort study in Iran.

Ahmadi, Ali. and Mosavi-Jarrahi, Alireza. and Pourhoseingholi, Mohamad Amin. (2015) Mortality determinants in colorectal cancer patients at different grades: a prospective, cohort study in Iran. Asian Pacific journal of cancer prevention : APJCP, 16 (3). pp. 1069-72. ISSN 2476-762X


Download (413kB) | Preview


BACKGROUND Colorectal cancer (CRC) is an important cause of mortality and morbidity in many communities worldwide. This population based study was conducted to assess determinants of colorectal mortality in Iranian patients. MATERIALS AND METHODS A cohort of 1,127 cases of confirmed colorectal cancer registered in a population based registry covering 10 referral hospital in Tehran, Iran, were followed for five years. Information about tumor characteristics, smoking status and family history were collected at base line and survival status were followed every six months by contacting patient or next of kin (if patients died during the follow-up). The cause of death for each case was validated by verbal autopsy and referring to patient medical records at the time of death. The data were analyzed by Stata software using univariate and multivariate analysis (Cox regression). In building the model a p value of less than 5% was considered as significant. RESULTS The age at diagnosis was 53.5±14 years. Sixty one percent were male. Colorectal mortality among the patients was 96.9 person-years among men and 83 person-years among women. Seventy five percent of patients lived for 2.72 years, 50% for 5.83, and 25% for 13 years after the diagnosis of colorectal cancer. The age at diagnosis was significantly different between men and women (p<0.03). Higher tumor grade predicted higher death rate; the adjusted hazard ratios were 1.79 (95%CI, 0.88-3.61), 2.16 (95%CI, 1.07-4.37), and 3.1 (95%CI, 1.51-6.34) for grades II, III, and IV respectively when they were compared with grade I as reference. Ethnicity, marital status, family history of cancer, and smoking were related to survival with different degrees of magnitude. CONCLUSIONS Among many factors related to survival among the colorectal patients, tumor grade and smoking showed the highest magnitudes of association.

Item Type: Article
Subjects: WI Digestive System
QZ pathology-Neoplasms
Divisions: Faculty of Health > Department of Epidemiology
Depositing User: zahra bagheri .
Date Deposited: 26 Jul 2017 06:06
Last Modified: 17 Apr 2018 07:45

Actions (login required)

View Item View Item