Effect of anti-cyclic citrullinated peptide and HLA-DRB1 subtypes on clinical disease activity index in rheumatoid arthritis patients

Soleimani, Akbar. and Mobedi, Zahra. and Al-E-Rasul, Maryam. and Sharifi, Abolghasem. and Kazemi Vardanjani, Abdolrahim. (2017) Effect of anti-cyclic citrullinated peptide and HLA-DRB1 subtypes on clinical disease activity index in rheumatoid arthritis patients. Journal of Clinical and Diagnostic Research, 11 (3). OC09-OC12.

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Abstract

Rheumatoid arthritis (RA) is a crippling disease with a global prevalence of approximately 0.5%-1% in adults. Genetic, environmental and immunologic factors contribute importantly to pathogenesis of RA. American College of Rheumatology (ACR) assists in early diagnosis of the disease. Aim: The aim of this study was to investigate the effects of HLA- DRB1 gene and anti-Cyclic Citrullinated Peptide (CCP) antibody on Clinical Disease Activity Index (CDAI) and to determine the frequency of HLA-DRB1 alleles in the patients with RA. Materials and Methods: In this descriptive-analytical study, 64 patients with RA referring rheumatology clinic of Hajar Hospital, Shahr-e-Kord, Iran were enrolled based on ACR criteria (1987) by convenience sampling. All patients were examined to assess primary CDAI and referred to laboratory for serologic tests [Rheumatoid Factor (RF) and anti-CCP]. After the patients’ DNA was extracted, HLA-DRB1 was determined per single specific primer-polymerase chain reaction by inno-train kits. The patients were re-examined six months later. Results: The most prevalent type of HLA-DRB1 in the studied patients was 04. In patients with HLA-DRB1 (04), HLA-DRB1 (01), and HLA-DRB1 (15), CDAI decreased pronouncedly after six months, but in other patients it did not (p<0.05). Of the patients, 81.3% had high titers of anti-CCP, but no association between anti-CCP and CDAI was found. Conclusion: RA could be a multifactorial disease. The patients with HLA-DRB1 (04), HLA-DRB1 (01) and HLA-DRB1 (15) showed a good response to routine treatments. The patients with HLA- DRB1 (04) are likely to have no decrease in secondary CDAI. High titers of anti-CCP in patients may indicate the severity of RA in the studied region and perhaps environmental, genetic and unknown or idiopathic factors are aetiologically crucial

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Human leukocyte antigen, Rheumatic diseases, Rheumatoid factor
Subjects: WE Musculoskeletal system
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Faculty of Medicine > Department of Clinical Sciences > Department of Orthopedics
Reserach Vice-Chancellar Department
Depositing User: Users 1 not found.
Date Deposited: 21 Jun 2017 07:15
Last Modified: 18 Feb 2018 10:51
URI: http://eprints.skums.ac.ir/id/eprint/178

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