Therapeutic effects of Ventolin versus hypertonic saline 3% for acute bronchiolitis in children.

Zamani, Mohammad Ali. and Movahhedi, Mehran. and Nourbakhsh, Seyyed Mohammad-Kazem. and Ganji, Forouzan. and Rafieian-Kopaei, Mahmoud. and Mobasheri, Mahmoud. and Khoshdel, Abolfazl. and Etemadifar, Shahram. and Shirani, Majid. and Keivani Hafshejani, zahra. (2015) Therapeutic effects of Ventolin versus hypertonic saline 3% for acute bronchiolitis in children. Medical journal of the Islamic Republic of Iran, 29. p. 212. ISSN 1016-1430

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Abstract

BACKGROUND Complications of Ventolin as the most common drug used for bronchiolitis are widely known. The present study was conducted to determine the efficacy of hypertonic saline 3%, compared with Ventolin, for treatment of acute bronchiolitis in children. METHODS This double-blinded clinical trial study was conducted in Hajar Hospital, Shahrekord, Iran, from 2011 to 2012. A total of 70 patients under the age of two years with bronchiolitis were divided into two groups of 35 each. Ventolin nebulizer and hypertonic saline 3% nebulizer three times per day were administered in the first (Ventolin) and second (Hypersaline) group, respectively. The length of recovery was compared between the two groups. The data were analyzed by SPSS software (version 22) using chi-square, t-test, paired t-test, and Mann-Whitney. RESULTS The mean±SD length of recovery was 4.14±0.9 and 3.06±0.6 in the Ventolin and hypersaline groups, respectively. The mean duration of recovery was significantly lower in the hypersaline group (p<0.001). CONCLUSION Hypertonic saline 3% nebulizer has more pleasant therapeutic effects on acute bronchiolitis than Ventolin. Therefore, use of hypertonic saline 3% nebulizer is recommended for the treatment of acute bronchiolitis in children under two years old.

Item Type: Article
Subjects: WF Respiratory System
WS Pediatrics
QV pharmacology > QV 704 Pharmaceutics
Divisions: Faculty of Health > Department of Epidemiology
Faculty of Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Community Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Pediatrics
Faculty of Medicine > Department of Clinical Sciences > Department of Surgery
Faculty of Nursing and Midwifery
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 25 Jul 2017 07:30
Last Modified: 07 Mar 2018 08:47
URI: http://eprints.skums.ac.ir/id/eprint/1716

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