Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd.

Rafieian-Kopaei, Mahmoud. and Suleimani dehkordi, Ibrahim. and Ghanadian, Mostafa. and Shokrollahi, Ardeshir. and Aghaei, Mahmoud. and Ayatollahi, Seyed Majid. and Choudhary, Iqbal. (2016) Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd. Natural product research, 30 (17). pp. 1927-33. ISSN 1478-6427

Full text not available from this repository.

Abstract

Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1), a new sesquiterpene: 4,9(α)-dihydroxy-nardosin-6-en (2) and an already known labdane-type diterpene: 15-hydroxy-8(17),13(E)-labdadiene-19-carboxilic acid (3). Compounds 1-3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines.

Item Type: Article
Uncontrolled Keywords: Cupressaceae; Juniperus foetidissima; bladder cancer cell; cytotoxicity; ovary cancer cell
Subjects: QU Biochemistry
QZ pathology-Neoplasms
QW Microbiology and Immunology
Divisions: Faculty of Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: zahra bagheri .
Date Deposited: 25 Jul 2017 07:16
Last Modified: 24 Jul 2018 03:17
URI: http://eprints.skums.ac.ir/id/eprint/1712

Actions (login required)

View Item View Item