Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress

Haj-Mirzaian, Arvin. and Amini-Khoei, Hossein. and Haj-Mirzaian, Arya. and Amiri, Shayan. and Ghesmati, Maria. and Zahir, Mazyar. and Shafaroodi, Hamed. and Dehpour, Ahmad Reza. (2017) Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress. Brain Research Bulletin, 130. pp. 200-210.


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Social isolation stress (SIS) paradigm is a chronic stress procedure able to induce profound behavioral and neurochemical changes in rodents and evokes depressive and anxiety-like behaviors. Recent studies demonstrated that the cannabinoid system plays a key role in behavioral abnormalities such as depression through different pathways; however, there is no evidence showing a relation between SIS and the cannabinoid system. This study investigated the role of the cannabinoid system in depressive-like behavior and anxiety-like behavior of IC animals. For this purpose, NMRI mice were treated with WIN55, 212-2 (non-selective cannabinoid receptor agonist) and AM-251 (cannabinoid receptor type 1 antagonist) and AM-630 (cannabinoid receptor type 2 antagonist). We found that behavioral abnormality followed by SIS was mitigated after administration of WIN55, 212-2. Also, depressive-like effects induced by SIS were significantly increased following administration of AM-251 and AM-630. Co-administration of cannabinoid receptor antagonists (AM-251 and AM-630), significantly reversed the antidepressant effect of WIN55, 212-2 in IC animals. Our findings suggest that the cannabinoid system is involved in depressive-like behaviors induced by SIS. We showed that activation of cannabinoid receptors (type 1 and 2) could mitigate depression-like behavior induced by SIS in a mouse model.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Cannabinoid receptors, Depressive-like behavior, Mouse, Social isolation stress
Subjects: WM Psychiatry
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 21 Jun 2017 05:26
Last Modified: 18 Feb 2018 09:17

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