Comparative Immune Response in Children and Adults with H. pylori Infection

Razavi, Alireza. and Bagheri, Nader. and Azadegan-Dehkordi, Fatemeh. and Shirzad, Mahsa. and Rahimian, Ghorbanali. and Rafieian-Kopaei, Mahmoud. and shirzad, Hedayatollah. (2015) Comparative Immune Response in Children and Adults with H. pylori Infection. JOURNAL OF IMMUNOLOGY RESEARCH.


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Helicobacter pylori (H. pylori) infection is generally acquired during early childhood; therefore, the immune response which usually takes place at this age may influence or even determine susceptibility to the infection contributing to the clinical outcomes in adulthood. Several cytokines including IL-6, IL-10, and TGF-beta 1 as well as Foxp(3+) cell numbers have been shown to be higher; however, some other cytokines consisting of IL-1 beta, IL-17A, and IL-23 are lower in infected children than in infected adults. Immune response to H. pylori infection in children is predominant Treg instead of Th17 cell response. These results indicate that immune system responses probably play a role in persistent H. pylori infection. Childhood H. pylori infection is also associated with significantly lower levels of inflammation and ulceration compared with adults. This review, therefore, aimed to provide critical findings of the available literature about comparative immune system in children and adults with H. pylori infection.

Item Type: Article
Subjects: WC Communicable Diseases
WS Pediatrics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 23 Jul 2017 03:21
Last Modified: 30 Jan 2018 08:37

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