Cardiovascular toxicity of cyclooxygenase inhibitors and promising natural substitutes

Bahmani, M. and Sarrafchi, A. and Shirzad, H. and Asgari, S. and Rafieian-Kopaei, M. (2017) Cardiovascular toxicity of cyclooxygenase inhibitors and promising natural substitutes. Current Pharmaceutical Design, 23 (6). pp. 952-960.

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are used for a wide variety of diseases including pain and inflammatory conditions such as osteoarthritis, rheumatoid arthritis, musculoskeletal disorders, and other comorbid complications. However, this group of drugs have undesirable effects such as peptic ulcer, bleeding and renal failure. Some of these side effects are associated with or caused by generation of oxidative stress. Following the withdrawal of a cyclo-oxygenase-2 (COX-2) inhibitor drug, rofecoxib (VIOXX®) due to cardiovascular complications, scientists suggested that natural COX-2 inhibitors might provide valuable alternatives to COX inhibitors. Although, most of medicinal plants reduce pain and inflammation in a similar manner to synthetic medications, however, they often have fewer side effects and are better tolerated. The present review other than focusing on cardiovascular and some other complications of NSAIDs, is trying to introduce the natural alternative remedies for these medications

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Cardiovascular, COX, Medicinal plants, NSAID, Oxidative stress, Toxicity
Subjects: WG Cardiovascular System
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 21 Jun 2017 04:55
Last Modified: 21 Jun 2017 04:55
URI: http://eprints.skums.ac.ir/id/eprint/166

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