Frequency of virulence factors in Helicobacter pylori-infected patients with gastritis

Salimzadeh, Loghman. and Bagheri, Nader. and Zamanzad, Behnam. and Azadegan-Dehkordi, Fatemeh. and Rahimian, Ghorbanali. and Hashemzadeh-Chaleshtori, Morteza. and Rafieian-Kopaei, Mahmoud. and Sanei, Mohammad Hossein. and shirzad, Hedayatollah. (2015) Frequency of virulence factors in Helicobacter pylori-infected patients with gastritis. MICROBIAL PATHOGENESIS, 80. pp. 67-72.

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Abstract

The outcome of Helicobacter pylori infection has been related to specific virulence-associated bacterial genotypes. The vacuolating cytotoxin (vacA), cagA gene, oipA and babA2 gene are important virulence factor involving gastric diseases. The objective of this study was to assess the relationship between virulence factors of H. pylori and histopathological findings. Material and methods: Gastroduodenoscopy was performed in 436 dyspeptic patients. Antrum biopsy was obtained for detection of H. pylori, virulence factors and for histopathological assessment. The polymerase chain reaction was used to detect virulence factors of H. pylori using specific primers. Results: vacA genotypes in patients infected with H. pylori were associated with cagA, iceA1 and iceA2. In the patients with H. pylori infection there was a significant relationship between cagA positivity and neutrophil activity (P = 0.004) and chronic inflammation (P = 0.013) and with H. pylori density (P = 0.034). Neutrophil infiltration was found to be more severe in the s1 group than in the s2 group (P = 0.042). Also was a significant relationship between oipA positivity and neutrophil activity (P = 0.004) and with H. pylori density (P = 0.018). No significant relationships were observed between other vacA genotypes and histopathological parameters. Conclusion: H. pylori strains showing cagA, vacA s1 and oipA positivity are associated with more severe gastritis in some histological features but virulence factors of H. pylori do not appear to determine the overall pattern of gastritis. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Helicobacter pylori; Virulence factors; Gastritis; PCR
Subjects: WC Communicable Diseases
WI Digestive System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 22 Jul 2017 07:04
Last Modified: 30 Jan 2018 08:47
URI: http://eprints.skums.ac.ir/id/eprint/1638

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