New insight to IL-23/IL-17 axis in Iranian infected adult patients with gastritis : effects of genes polymorphisms on expression of cytokines

shirzad, Hedayatollah. and Bagheri, Nader. and Azadegan-Dehkordi, Fatemeh. and Zamanzad, Behnam. and Izadpanah, Esmail. and Abdi, Mohammad. and Ramazani, Ghasem. and Sanei, Mohammad Hossein. and Ayoubian, Hiresh. and Ahmadi, Abbas. and Jamalzehi, Sirous. and Aslani, Parya. and Zandi, Farid. (2015) New insight to IL-23/IL-17 axis in Iranian infected adult patients with gastritis : effects of genes polymorphisms on expression of cytokines. ACTA GASTRO-ENTEROLOGICA BELGICA, 78 (2). pp. 212-218.

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Abstract

Background and Objective : Chronic inflammation is the hallmark of the pathogenesis of H. pylori-induced gastric cancer. IL-17A and IL-17F are inflammatory cytokines expressed by a novel subset of CD4(+)Th cells and play critical function in inflammation. We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-beta 1 mRNAs expression in regard to H. pylori infection with chronic gastritis. Materials and Methods : Total RNA and genomic DNA were extracted from gastric biopsies of 58 H. pylori-infected patient with gastritis. Afterward, mucosal IL-6, IL-17, IL-21, IL-23 and TGF-beta 1 mRNAs expression and polymorphisms in IL-17A G197A, IL-17F A7488G and IL-23R +2199A/Cin gastric biopsies were determined by real-time PCR and PCR-RFLP. Results : Our results show that IL-17A G197A, IL-17F A7488G andIL23R +2199A/C polymorphisms have no effect on mucosal expression of IL-6, IL-17, IL-21 and TGF-beta 1 mRNAs expression in H. pylori-infected patients with chronic gastritis. Conclusion : These results suggest that IL-17A G197A, IL-17F A7488G and IL23R +2199A/C polymorphisms no alter mucosal cytokine pattern in Iranian patients with H. pylori-associated gastritis diseases.

Item Type: Article
Uncontrolled Keywords: H. pylori; polymorphism; chronic gastritis
Subjects: WI Digestive System
QU Biochemistry
Divisions: Faculty of Nursing and Midwifery
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 22 Jul 2017 05:08
Last Modified: 30 Jan 2018 08:55
URI: http://eprints.skums.ac.ir/id/eprint/1627

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