Correlation Between Mucosal IL-6 mRNA Expression Level and Virulence Factors of Helicobacter pylori in Iranian Adult Patients With Chronic Gastritis

Azadegan-Dehkordi, Fatemeh. and Bagheri, Nader. and Shirzad, Mahsa. and Sanei, Mohammad Hossein. and Hashemzadeh-Chaleshtori, Morteza. and Rafieian-Kopaei, Mahmoud. and Tabatabaiefar, Mohammad Amin. and shirzad, Hedayatollah. (2015) Correlation Between Mucosal IL-6 mRNA Expression Level and Virulence Factors of Helicobacter pylori in Iranian Adult Patients With Chronic Gastritis. JUNDISHAPUR JOURNAL OF MICROBIOLOGY, 8 (8).

[img]
Preview
Text
42.pdf

Download (602kB) | Preview

Abstract

Background: Helicobacter pylori infection is associated with gastritis and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells that contribute to sustained local inflammation. In this study, we sought to examine IL-6 expression in H. pylori-infected and uninfected gastric mucosa and elucidate the implication in the pathogenesis of H. pylori-associated gastritis in human. Objectives: The current study aimed to determine mucosal IL-6 mRNA expression level and their correlation with virulence factors and the grade of chronic gastritis among H. pylori infected patients with chronic gastritis from Shahrekord, Iran. Patients and Methods: Mucosal IL-6 mRNA levels was measured by real-time PCR using endoscopic biopsies taken from the gastric antrum of 58 subjects infected with H. pylori and 44 uninfected subjects. Presence of vacA and cagA virulence factors was evaluated using PCR. Results: The IL-6 mRNA expression levels were significantly more elevated in H. pylori-positive patients than uninfected individuals and expression of this cytokine was independent from the virulence factors. There was a correlation between IL-6 expression level and the grade of chronic gastritis. Conclusions: Enhanced induction of IL-6 may be involved in the pathogenesis of H. pylon-associated gastritis.

Item Type: Article
Uncontrolled Keywords: Gastritis; IL-6; Virulence Factors; Helicobacter pylori
Subjects: WI Digestive System
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 19 Jul 2017 09:24
Last Modified: 30 Jan 2018 08:41
URI: http://eprints.skums.ac.ir/id/eprint/1603

Actions (login required)

View Item View Item