Comparison of the effects of Crataegus oxyacantha extract, aerobic exercise and their combination on the serum levels of ICAM-1 and E-Selectin in patients with stable angina pectoris

Jalaly, Leila. and Sharifi, Gholamreza. and Faramarzi, Mohammad. and Nematollahi, Alireza. and Rafieian-Kopaei, Mahmoud. and Amiri, Masoud. and Moattar, Fariborz. (2015) Comparison of the effects of Crataegus oxyacantha extract, aerobic exercise and their combination on the serum levels of ICAM-1 and E-Selectin in patients with stable angina pectoris. DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 23.

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Abstract

Background: Adhesion molecules play an important role in the development and progression of coronary atherosclerosis. The aim of this study was comparing the effect of Cratagol herbal tablet, aerobic exercise and their combination on the serum levels of Intercellular adhesion molecule (ICAM)-1 and E-Selectin in patients with stable angina pectoris. Methods: Eighty stable angina pectoris patients aged between 45 and 65 years, were randomly divided into four groups including three experimental groups and one control group: aerobic exercise (E), Crataegus oxyacantha extract (S), aerobic exercise and Crataegus oxyacantha extract (S+E), and control (C). Blood sampling was taken 24 h before and after 12 weeks of aerobic exercise and Crataegus oxyacantha extract consumption. The results of serum levels of ICAM-1 and E-selectin were compared. Results: Intergroup comparison of the data revealed a significant reduction (P < 0.01) in serum levels of ICAM-1 and E-selectin in experimental groups. Analysis of data showed that the serum levels of ICAM-1 had significant difference when group S+E was compared with groups S and C, but not group E (P = 0.021, P = 0.000 and P = 0.068, respectively). Also the difference between the levels of E-selectin was significant comparing S+E and S but not E with group C (P = 0.021, P = 0.000 and P = 0.052, respectively). Conclusions: Twelve weeks effects of aerobic exercise and Crataegus oxyacantha extract consuming is an effective complementary strategy to significantly lower the risk of atherosclerosis and heart problems.

Item Type: Article
Uncontrolled Keywords: Aerobic exercise; Cratagol; ICM-1; E-selectin; Stable angina pectoris
Subjects: WG Cardiovascular System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Cardiology
Reserach Vice-Chancellar Department > Medical Plants Research Center
Reserach Vice-Chancellar Department > Modeling in Health Research Center
Depositing User: Users 1 not found.
Date Deposited: 19 Jul 2017 04:29
Last Modified: 21 Feb 2018 10:57
URI: http://eprints.skums.ac.ir/id/eprint/1564

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