The effects of Vitamin C on sperm quality parameters in laboratory rats following long-Term exposure to cyclophosphamide

Shabanian, S. and Farahbod, F. and Rafieian, M. and Ganji, F. and Adib, A. (2017) The effects of Vitamin C on sperm quality parameters in laboratory rats following long-Term exposure to cyclophosphamide. Journal of Advanced Pharmaceutical Technology and Research, 8 (2). pp. 73-79.

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Abstract

Cyclophosphamide is a widely used medication and can cause oxidative stress. This study was conducted to investigate the effects of Vitamin C on reproductive organs' weight and the quality of sperm parameters in laboratory rats. In this experimental study, 40 rats were randomly assigned into five groups of eight each. Distilled water (DW) group received only food and water, Group 2 was administered with drug solvent (DW) by gavage, Group 3 intraperitoneally administered with 1.6 mg/kg cyclophosphamide, Group 4 gavaged Vitamin C at 0.88 mg/kg, and Group 5 administered with effective doses of Vitamin C and cyclophosphamide by gavage with 1-h intervals. Sperm parameters of the samples were taken from distal epididymis and tissues were studied, and the data were analyzed by SPSS version 22. The lowest weight of testicles and epididymis was seen in cyclophosphamide-exposed rats and the highest weight of testicles and epididymis in Vitamin C-exposed rats (P < 0.05). The highest motility, progression, viability, and count of sperm were seen in the Vitamin C-Treated group and the lowest in the cyclophosphamide-exposed group. The highest proportion of sperm anomalies was seen in the cyclophosphamide-exposed group. Vitamin C, as an antioxidant, can be effective on some of the sperm parameters and can reduce cyclophosphamide-induced complications in animal model. © 2017 Journal of Advanced Pharmaceutical Technology & Research | Published by Wolters Kluwer -Medknow.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Ascorbic acid, cyclophosphamide, spermatozoa
Subjects: WJ Urogenital System
QU Biochemistry
Divisions: Faculty of Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Community Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 20 Jun 2017 08:10
Last Modified: 20 Jun 2017 08:10
URI: http://eprints.skums.ac.ir/id/eprint/155

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