Study of common mitochondrial mutations in patients with nonsyndromic hearing loss

Mahmoudian Sani, M. and Mehri-Ghahfarrokhi, A. and Ahmadi, H. and Shojaeian, A. and Hashemzadeh-Chaleshtori, M. and Mahdavinezhad, A. and Saidijam, M. (2017) Study of common mitochondrial mutations in patients with nonsyndromic hearing loss. Otorinolaringologia, 67 (2). pp. 61-67.

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Abstract

Hearing loss is the most common sensorineural disorder involving one out of 1000 people. Around 50% of hearing losses occur due to genetic causes. Three mitochondrial mutations, A1555G in MTRNR1, A3243G in MTTL1, and A7445G in MTTS1, are the most important non-syndromic sensorineural causes of hearing loss in some populations. The aim of this review was to study common mitochondrial mutations in people with hearing loss in Iran. EVIDENCE ACQUISITION: Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science were searched. EVIDENCE SYNTHESIS: Studies have indicated that the mitochondrial mutations A3243G, A1555G, and A7445G play no significant part in the development of hearing loss in Iran. Different variants of A7445C and G3316A have been identified in Iran. CONCLUSIONS: Further studies on other ethnicities and with a larger sample size are necessary to elucidate the role of these genes in hearing loss development in Iran.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Disease susceptibility, Hearing loss ,Mutation
Subjects: WV Otolaryngology
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 19 Jun 2017 06:51
Last Modified: 19 Jun 2017 08:54
URI: http://eprints.skums.ac.ir/id/eprint/140

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