Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial.

Eftekhar, Maryam and Miraj, Sepideh and Farid Mojtahedi, Maryam and Neghab, Nosrat (2016) Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial. International journal of reproductive biomedicine (Yazd, Iran), 14 (11). pp. 687-690. ISSN 2476-4108

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Abstract

BACKGROUND Although pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure. OBJECTIVE The aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failure. MATERIALS AND METHODS 0.5 ml (300 µg/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy. RESULTS The mean age of participants was 31.95±4.71 years old. There were no significant differences between demographic characteristics in two groups (p>0.05). The pregnancy outcome in GCSF group was improved significantly (p=0.043). CONCLUSION GCSF can improve pregnancy outcome in patients with history of implantation failure.

Item Type: Article
Uncontrolled Keywords: GCSF; Pregnancy rate; In vitro fertilization
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Depositing User: zahra bagheri .
Date Deposited: 15 Jul 2017 06:20
Last Modified: 15 Jul 2017 06:20
URI: http://eprints.skums.ac.ir/id/eprint/1338

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