Association of TIM-1 5383-5397ins/del and TIM-3-1541C > T polymorphisms with multiple sclerosis in Isfahan population

Mazrouei, Fariba. and Ganjalikhani-Hakemi, Mazdak. and Salehi, Rasoul. and Alesahebfosoul, Fereshteh. and Etemadifar, Masoud. and Pouladian, Majid. and Meshkat, Rezvan. and Nekoueian, Sh. and Zarkesh Esfahani, Hamid. and Ziyaee-Ghahnaviyeh, M. (2016) Association of TIM-1 5383-5397ins/del and TIM-3-1541C > T polymorphisms with multiple sclerosis in Isfahan population. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 43 (3). pp. 131-134.

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Abstract

Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in autoimmune diseases. In this study, for the first time, the association of TIM-1 5383-5397ins/del and TIM-3 -1541C>T polymorphisms with MS in an Iranian population was considered. The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and MS (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS (P = 0.009, OR = 4.08).

Item Type: Article
Subjects: WL Nervous system
Divisions: Faculty of Medicine > School of Medicine
Depositing User: Users 1 not found.
Date Deposited: 16 Jul 2017 05:44
Last Modified: 28 Mar 2018 04:03
URI: http://eprints.skums.ac.ir/id/eprint/1183

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