Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd

Rafieian-Kopaei, Mahmoud. and Suleimani dehkordi, Ibrahim. and Ghanadian, Mostafa. and Shokrollahi, Ardeshir. and Aghaei, Mahmoud. and Ayatollahi, Seyed Majid. and Choudhary, Iqbal. (2016) Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd. Natural Product Research, 30 (17). pp. 1927-1933.

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Abstract

Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1), a new sesquiterpene: 4,9(α)-dihydroxy-nardosin-6-en (2) and an already known labdane-type diterpene: 15-hydroxy-8(17),13(E)-labdadiene-19-carboxilic acid (3). Compounds 1–3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: bladder cancer cell, Cupressaceae, cytotoxicity, Juniperus foetidissima, ovary cancer cell
Subjects: QZ pathology-Neoplasms
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: zahra bagheri .
Date Deposited: 09 Jul 2017 09:10
Last Modified: 25 Feb 2018 06:47
URI: http://eprints.skums.ac.ir/id/eprint/1073

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