Oxidative stress and age-related changes in T cells: Is thalassemia a model of accelerated immune system aging?

Ghatreh-Samani, M. and Esmaeili, N. and Soleimani, M. and Asadi-Samani, M. and Ghatreh-Samani, K. and Shirzad, H. (2016) Oxidative stress and age-related changes in T cells: Is thalassemia a model of accelerated immune system aging? Central European Journal of Immunology, 41 (1). pp. 116-124.

[img]
Preview
Text
24.pdf

Download (188kB) | Preview
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Iron overload in β-thalassemia major occurs mainly due to blood transfusion, an essential treatment for β-thalassemia major patients, which results in oxidative stress. It has been thought that oxidative stress causes elevation of immune system senescent cells. Under this condition, cells normally enhance in aging, which is referred to as premature immunosenescence. Because there is no animal model for immunosenescence, most knowledge on the immunosenescence pattern is based on induction of immunosenescence. In this review, we describe iron overload and oxidative stress in β-thalassemia major patients and how they make these patients a suitable human model for immunosenescence. We also consider oxidative stress in some kinds of chronic virus infections, which induce changes in the immune system similar to β-thalassemia major. In conclusion, a therapeutic approach used to improve the immune system in such chronic virus diseases, may change the immunosenescence state and make life conditions better for β-thalassemia major patients. © 2016 Termedia Sp. z o.o. All rights reserved.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: Antioxidant therapy, Iron overload, Oxidative stress, β-thalassemia major
Subjects: WH Hemic and Lymphatic System
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Reserach Vice-Chancellar Department > student research center
Depositing User: zahra bagheri .
Date Deposited: 15 Jul 2017 06:37
Last Modified: 15 Jul 2017 06:37
URI: http://eprints.skums.ac.ir/id/eprint/1014

Actions (login required)

View Item View Item